Astymin: Uses, Dosage, Side Effects and Composition

Description of Astymin

Astymin liquid or capsule is a  unique formulation containing pure crystalline Amino acids in known quantities together with Vitamins. Astymin liquid is designed to supplement amino acids, Vitamins and Mineral needed to promote growth.

Composition of Astymin

What does astymin contain?

Each 15 ml or one capsule of Astymin Contains:

• L-leucine USP 18.3 mg
• L-isoleucineUSP 5.9mg
• L-lysine hydrochlonde USP 25 mg
• L-phenylalanine USP  5 mg-
• L-threonine USP 4.2mg
• L-methionine USP 9.2mg
• L-tryptophan USP 5 mg
• L-valine USP 6.7 mg-
• Thiamine hydrochloride BP 5 mg-
• Riboflavin (as riboflavin sodium phosphate) BP 3 mg
• Pyridoxine hydrochloride BP 1.5 mg
• Nicotinamide BP 25 mg
• Calcium pantothenate BP 5 mg
• Cyanocobalamin BP 2.5 mcg
• Folic acid BP 0.75 mg
• Ascorbic acid BP 40 mg
• Vitamin A (as synthetic retinol concentrate oily form) BP 200 l.U.
• ColecalciferolBP 200 I.U.
• Alpha tocopheryl acetate BP 7.5 I.U.

Pharmacological action of Astymin

Amino acids are the basic building blocks of proteins and enzymes and are essential for normal healthy bodily function especially during growth and convalescence.  The essential amino acids cannot be made in the body and must be included in the diet or Vitamins as a supplement.

Vitamins B1, B2, B6 and nicotinamide are parts of co-enzyme systems concerned with release of energy from foodstuffs. Like the essential amino acids and minerals, they cannot be made in the body and must be included in the diet in small quantities. The B-complex vitamins are water-soluble and are not stored in the body in appreciable amounts. Consequently, regular replenishment of these vitamins is required. Their presence prevents the development of certain deficiency diseases such as beri-beri, riboflavinosis and pellagra.

Indications and Uses of Astymin:

What is astymin used for ?

1. Astymin is indicated in the treatment of patients with deficiencies of or increased requirements of Amino Acids and Vitamins in:

• Malnutrition
• Stress
• Convalescence
• Debility
• Following Injury
• Active growth

1. As an adjunct to:

• Antibiotics
• Anti Hypertensives
• Anti TB Drugs
• Anti Malarial Drugs
• Anti Viral Drugs

1. In General, Astymin Promotes active growth and replacement of body tissues. Helps relieve fatigue and stress and improves general well being.

Dosage of Astymin

What is the dosage of astymin ?

15ml (one tablespoon full) or a capsule of Astymin is to be taken twice (12 hourly) daily or as directed by the physician.

Contraindications of Astymin:

When should I not take astymin?

Hypersensitivity to any of the ingredients. Pantothenol is contraindicated haemophiliacs and in patients with ileus due to mechanical obstruction.

Pregnancy and lactation:

Can pregnant and lactating mothers take astymin?

• Excessive doses of Vitamin A should be avoided in pregnancy because potential teratogenic effects.
• Lactating women should not take vitamin D if possible, as this may lead to the development of hypercalcaemia in the infant.

Drug interaction of Astymin:

What drug should i not take while taking astymin ?

• Vitamin A: Absorption  of vitamin A from the gastrointestinal tract may be reduced by the presence of neomycin, cholestyramine, or liquid paraffin absorption may also be impaired in cholestatic jaundice and fat malabsorption conditions.
• Vitamin B6: Reduces the effects of levodopa
• Vitamin D: The effects of Vitamin D may be reduced in patients taking barbiturates or anticonvulsants.

Side Effects of Astymin:

Does astymin have any side effect ?

• Vitamin C Large doses may cause diarrhoea and other gastrointestinal disturbances and are associated with the formation of renal calcium oxalate calculi. Vitamin C should be given with care to patients with hyperoxaluria. Tolerance may be induced with prolonged use of large doses.

For more details: See Harmful Effects of Vitamin C

• Vitamin D: Should not be administered to patients with hypercalcaemia, and be given with caution to infants, as they may have increased sensitivity to its effects.

Symptoms of Astymin Overdosage and its Treatments

Does astymin have overdose effects ?

• Vitamin A: Excessive amounts over long periods can lead to toxicity, known as hypervitaminosis A characterised by fatigue, irritability and loss of weight, vomiting and other gastro-intestinal disturbances, low-grade fever, hepatosplenomegaly, skin changes, alopecia, dry hair, cracking and bleeding lips, anaemia headache, hypercalcaemia, subcutaneous swelling, and pains in bones and joints. Symptoms of chronic toxicity in children may also include raised intracranial pressure and papilloedema mimicking brain tumours, tinnitus visual disturbances which may be severe, and painful swelling over the long bones. Symptoms usually clear on withdrawal of vitamin A, but in children premature close of the epiphyses of the long bones may result in arrested bone growth Acute vitamin A intoxication may occur with very high doses and in characterised by sedation, dizziness, nausea and vomiting, erythema, pruritus and desquamation.
• Vitamin B6: Long-term administration of large doses of pyridoxine is associated with the development of severe peripheral neuropathies.
• Vitamin D: Excessive  intake of vitamin D leads to the development of hyper calcaemia which is characterised by anorexia, nausea, vomiting, constipation abdominal pain, muscle weakness, mental disturbances, polyuria, bone pain, nephrocalcinosis, renal calculi, and in severe cases cardiac arrhythmias and coma.