Description and Composition of Devofloxin
Pharmacology and Mechanism of Action of DevofloxinDevofloxin is a broad-spectrum antibiotic active against both Gram positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.
Pharmacokinetics of Devofloxin
Indications and Uses of DevofloxinAntibiotics usage including devofloxin should be guided by Microscopy, Culture and Sensitivity test result or standard treatment guidelines of a particular country or region where MCS test is not possible. Levofloxacin is used in the treatment of susceptible bacterial infections including:
- Acute bacterial sinusitis
- Acute bacterial exacerbations of chronic bronchitis
- Urinary tract infections
- Bacterial Gastroenteritis
- Bone and soft tissue infections
- Gynaecological and wound infections
- Respiratory infections (nosocomial or Community acquired pneumonia)
- Acute pyelonephritis
- Chronic bacterial prostatitis
- Gram negative septicaemia
- Meningitis Prophylaxis and Conjunctivitis
- Skin and skin structure infections
Contraindications of Devofloxin
Dosage of DevofloxinDevofloxin should be administered as per the directions given by the physician. Levofloxacin tablet should be swallowed without crushing and with sufficient amount of liquid. The tablets can be taken with or without food.
Acute bacterial sinusitisAdult: 500mg daily for 10 to 14 or 750mg daily for 5 days.
Acute bacterial exacerbation of chronic bronchitisAdult: 500 mg daily for 5 days
Urinary tract infectionsComplicated or acute pyelonephritis: 750 mg daily for 5 days Uncomplicated: 250 mg daily for 10 days Uncomplicated: 250 mg daily for 3 days
Nosocomial pneumonia750 mg daily for 7 to 10 days
Community acquired pneumonia750 mg daily for 5 days 500 mg daily 7 to 10 days
Skin and skin structure infectionsComplicated: 750 mg daily for 7 to 10 days Uncomplicated: 500 mg daily for 7 to 10 days
Chronic bacterial prostatitis500 mg daily for a month (28 days)
PlagueAdult and Children weighing 50 kg and above: 500 mg daily for 10 to 14 days Children: (30 kg to 50 kg): 250 mg 12 hourly for 10 to 14 days
Post exposure therapy for inhalational anthraxAdult and Children weighing up to 50 kg: 500 mg daily for 2 months (60 days) Paediatric patients: 30 kg to 50 kg: 250 mg 12 hourly for 60 days
Acne vulgaris (Off label)100 mg PO tds for a month (28 days)
Epididymitis (off label)500 mg PO daily for 10 days
Overdosage of Devofloxin
Side Effects of DevofloxinSide effects associated with the use of devofloxin may include:
- Diarrhoea or constipation
- Stomach upset
Drug Interactions with Devofloxin
- BCG vaccine live,
- Typhoid vaccine live
- Strontium ranelate
- Aluminium hydroxide
- Cholera vaccine
- Cyclosporin A
- Multivitamins with minerals
- Phenytoin Na
- Warfarin Na.
Devofloxin Disease InteractionsDevofloxin interacts with the following disease conditions
- CNS disorders
- Myasthenia gravis
- Peripheral neuropathy
- Renal dysfunction
- QT interval prolongation
Use of Devofloxin in Pregnancy and Lactation
Storage of DevofloxinStore below 30°C in a cool & dry place. Keep all medicines out of reach of children.
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