Description and Composition of Efonrex
Pharmacology and Mechanism of Action of EfonrexEfonrex is a synergistic combination of artemisinin derivative (artesunate) and an antimalarial (amodiaquine). It is very potent against the asexual forms of plasmodium, schizonts and gametocytes. The schizonticidal action of efonrex Insures a rapid clearance of, parasitaemia, ensuring a rapid clinical recovery, and its gametocidal action prevents the infestation. The half life of artesunate is short whereas amodiaquine is long. The absorption of efonrex after oral administration is rapid and complete; it is extensively distributed in all tissues.
Indications and Uses of Efonrex
Contraindications of EfonrexLinking to Amodiaquine: Efonrex must not be used in the following cases namely: hypersensitivity to one of the constituents, history of fever disease or blood impairment during an anterior treatment with amodiaquine and retinopathy (in the event of frequent treatment). Do not use this medicine during the pregnancy and the lactation. Linking to Artesunate: For now no recorded contraindication is reported, however, this drug must not be used in case of hypersensitivity to one of the constituents.
Interactions of Efonrex
Warnings and Precautions on Efonrex
Use in PregnancyThe use of camosunate is not recommended during the organogenesis period except if, in the doctor’s opinion, the benefits outweigh the risks as seen with cerebral malaria. Administration of the drug during the first trimester must be avoided.
Breast feedingArtesunate is not known to cross into maternal milk. Do not exceed the recommended dose without seeking further medical advice. Keep this medicine out of the reach of children.
Side Effects of Efonrex
Symptoms of Overdose of EfonrexYou should stop the treatment and consult immediately a Doctor or a Pharmacist in case of headache, dizziness, visual disturbances, convulsions. These symptoms usually indicate an overdose.
Dosage and Administration of Efonrex
Under one yearEach paediatric sachet containing Artesunate 25 mg and Amodiaquine base 75 mg should be dissolved in 10 ml clean water and taken daily for 3 days
1-6 yearsEach children sachet containing Artesunate 50 mg and Amodiaquine base 150 mg should be dissolved in 30 ml clean water and taken daily for 3 days
7-13 yearsOne tablet of each white tablet (Artesunate 100 mg) and one tablet of each yellow tablet (Amodiaquine hydrochloride equivalent to Amodiaquine base 300 mg) daily for 3 days.
14 years and aboveOne tablet of each white tablet (Artesunate 100 mg) and One tablet of each yellow tablet (Amodiaquine hydrochloride equivalent to Amodiaquine base 300 mg) in the morning and evening daily for 3 days.
Preparation for UseUnder one year – Each paediatric sachet containing Artesunate 25 mg and Amodiaquine 75 mg should be dissolved into 10 ml clean water and taken base daily for 3 days. 1-6 years Each children sachet containing Artesunate 50 mg and Amodiaquine base 150 mg should be dissolved in 30 ml clean water and taken daily for 3 days.
Pharmaceutical forms and Presentations of Efonrex
Tablet1 blister of 12 tablets contains 6 white Artesunate tablets and 6 yellow Amodiaquine tablets. (ADULT) 1 blister of 6 tablets contains 3 white Artesunate tablets and 3 yellow Amodiaquine tablets. (JUNIOR).
SachetsOne box of 6 sachets contains 3 white labelled Artesunate sachets and 3 black labelled Amodiaquine sachets.
Storage Conditions of EfonrexDo not exceed the expired date indicated on the outside packaging. Keep it in the original packet and store dry below 30°C.
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