Klovinal: Uses, Dosage, Side Effects, and Composition

Description and Composition of Klovinal

Klovinal Pessary is a formulation specially made for the treatment of mixed vaginal infections. It is a combination of different drugs and each Klovinal Pessary contains the following active ingredients listed below:

  1. Metronidazole BP 500 mg
  2. Clotrimazole BP 100mg
  3. Lactobacillus Spores 150 millions

In addition to the above listed active ingredients, Klovinal pessary contains inactive ingredients called excipients in sufficient quantities. It is white to off white bullet shaped Pessaries. The bullet shape allows for easy insert into the vagina.

Pharmacodynamics of Klovinal Pessary


Clotrimazole is a broad spectrum antifungal agent available for topical or Intravaginal use. It is active against yeast and dermatophytes and also some action against Gram +ve bacteria, especially Staphylococci and against Trichomonas. Clotrimazole acts by altering the permeability of fungal cell walls by interfering with cell wall lipids.


Metronidazole is active against several protozoa including Trichomonas Vaginalis. It is bactericidal, Metronidazole is used in the treatment of susceptible protozoal infections and in the treatment and prophylaxis of anaerobic infections. Specific bacterial infections treated with Metronidazole include bacterial vaginosis (nonspecific vaginitis).

Lactobacillus Spores

The vagina is dynamic ecosystem that normally contains approximately 10 bacterial colony forming units per gram of vaginal fluid. The normal bacterial flora is dominated by Lactobacilli. Lactic acids and other organic acids are metabolized from glycogen by the lactobacilli, maintaining the vaginal pH between 3.8 and 4.2.The acidic enviroment inhibits the overgrowth of bacteria and other organisms with pathogenic potential. Because of vaginal infections like bacterial vaginosis, trichomoniasis and vulvovaginal candidiasis, the Lactobacilli flora goes down and vaginal pH Increases to more than 4.5. Because of anaerobic bacteria, musty or fishy odour starts.

Lactobacillus is in spore form. It is used to recolonize the vaginal flora and to maintain the vaginal pH between 3.8 to 4.2.

Pharmacokinetics of Klovinal Pessary

When applied topically Clotrimazole penetrates the epidermis but there is little if any systemic absorption has been reported following vaginal administration Absorption of Metronidazole from vaginal Pessaries has been reported to be poor. Lactobacillus sporogenes recolonize the vaginal flora.

Indications and Uses of Klovinal Pessary

KLOVINAL Pessary is indicated for vaginal infections like trichomoniasis, bacterial vaginosis and vulvovaginal candidiasis.

Dosage of Klovinal Pessary

One KLOVINAL Pessary should be inserted into the vagina as deeply as possible once daily. It should be used for 6 days, preferably on retiring to bed at night.

Can Klovinal Pessary Be Used During Period (Menstruation)

Using Klovinal or any other pessaries during the menstrual period should not be performed due to the risk of the pessary being washed out by the menstrual flow.

Meanwhile, in a situation where you are already using Klovinal Pessary before your menstrual period started, then switch to an oral treatment if available or continue with the Klovinal Pessary until you complete it as prescribed by your doctor. When in doubt, always contact your healthcare provider.

Contraindications of Klovinal Pessary

When is Klovinal not to be used?

KLOVINAL Pessary is contraindicated in patients known to be hypersensitive to topical imidazoles and any of its ingredients.

Warning and Precautions

If irritation or sensitivity developes with the use of KLOVINAL Pessary, treatment should be discontinued and appropriate therapy instituted. If there is lack of response to KLOVINAL Pessary treatment, microbiological studies should be done to confirm the diagnosis and rule out other pathogens before instituting other course of antimycolytic therapy.

Pregnancy and lactation

Is Klovinal Pessary safe in pregnancy and breastfeeding women? Can it be used by these women without issues to their babies?

Klovinal pressary should only be given to pregnant or lactating mother if benefits outweigh the possible risk to the fetus.


Can Klovinal Pessary be taking or used together with other drugs?

Antibiotics with activity against lactobacilli should be avoided.

Adverse Reactions of Klovinal Pessary

Few patients have reported local pruritis and burning sensation after vaginal administration. Other Adverse reactions or side effects can occur while using this drug. Please inform your healthcare provider when you observe an unusual occurrences why using this drug.

Overdosage of Klovinal

Data not available


How to safely store Klovinal Pessary.

Keep in a dry place, below 30°C. Protect from light. Keep out of reach and sight of children.


KLOVINAL Strip of 6 Pessaries packed in a carton along with leaflet.

How to use Pessaries

  1. Wash your hands
  2. Do not open pessary if it seems soft, hold the foil wrapper under cold water or place it in refrigerator for few minutes to harden it before removing the wrapper
  3. Remove one pessary from the strip and hold it in fingertips
  4. Remove any foil or plastic wrapping stuck to the pessary.
  5. Sit or lie down with your knees bent and legs apart.
  6. Gently insert the pessary into the vagina as far as comfortably possible using your fingers.
  7. Wash your hands again.

Picture of Klovinal Pessary


Klovinal pessaries


How to Insert Pessaries into Applicator

To insert a pessary into an applicator, wash your hands thoroughly with soap under running water. Then dry it. This is followed by opening of the Pessary as shown in the video below. After that, remove the suppository and insert it into the applicator.

How to insert pessaries into the vagina

Watch the video below for a demonstration of how to insert vagina suppository into the vagina using an applicator.

Klovinal Pessary is marketed in Nigeria SEAGREEN PHARMACEUTICALS LTD.

3, Okunfolami Street, Anthony Village, Lagos.

It is manufactured by BLISS GVS PHARMA LTD.


Do you need to know more about your drugs?

Do you have a need to talk to a pharmacist?

Then use the button below to chat a pharmacist