Description and Composition of S-Flox
Pharmacology and Mechanism of Action of S-FloxS-Flox is a broad-spectrum antibiotic active against both Gram positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.
Pharmacokinetics of S-Flox
Indications and Uses of S-FloxAntibiotics usage including S-Flox should be guided by Microscopy, Culture and Sensitivity test result or standard treatment guidelines of a particular country or region where MCS test is not possible. S-Flox is used in the treatment of susceptible bacterial infections including:
- Acute bacterial sinusitis
- Acute bacterial exacerbations of chronic bronchitis
- Urinary tract infections
- Bacterial Gastroenteritis
- Bone and soft tissue infections
- Gynaecological and wound infections
- Respiratory infections (nosocomial or Community acquired pneumonia)
- Acute pyelonephritis
- Chronic bacterial prostatitis
- Gram negative septicaemia
- Meningitis Prophylaxis and Conjunctivitis
- Skin and skin structure infections
Contraindications of S-Flox
Dosage of S-FloxS-Flox should be administered as per the directions given by the physician. S-Flox tablet should be swallowed without crushing and with sufficient amount of liquid. The tablets can be taken with or without food.
Acute bacterial sinusitisAdult: 500mg daily for 10 to 14 or 750mg daily for 5 days.
Acute bacterial exacerbation of chronic bronchitisAdult: 500 mg daily for 5 days
Urinary tract infectionsComplicated or acute pyelonephritis: 750 mg daily for 5 days Uncomplicated: 250 mg daily for 10 days Uncomplicated: 250 mg daily for 3 days
Nosocomial pneumonia750 mg daily for 7 to 10 days
Community acquired pneumonia750 mg daily for 5 days 500 mg daily 7 to 10 days
Skin and skin structure infectionsComplicated: 750 mg daily for 7 to 10 days Uncomplicated: 500 mg daily for 7 to 10 days
Chronic bacterial prostatitis500 mg daily for a month (28 days)
PlagueAdult and Children weighing 50 kg and above: 500 mg daily for 10 to 14 days Children: (30 kg to 50 kg): 250 mg 12 hourly for 10 to 14 days
Post exposure therapy for inhalational anthraxAdult and Children weighing up to 50 kg: 500 mg daily for 2 months (60 days) Paediatric patients: 30 kg to 50 kg: 250 mg 12 hourly for 60 days
Acne vulgaris (Off label)100 mg PO tds for a month (28 days)
Epididymitis (off label)500 mg PO daily for 10 days
Overdosage of S-Flox
Side Effects of S-FloxSome side effects associated with the use of S-Flox may include:
- Diarrhoea or constipation
- Stomach upset
Drug Interactions with S-Flox
- BCG vaccine live,
- Typhoid vaccine live
- Strontium ranelate
- Aluminium hydroxide
- Cholera vaccine
- Cyclosporin A
- Multivitamins with minerals
- Phenytoin Na
- Warfarin Na.
Sflox Disease InteractionsSflox interacts with the following disease conditions
- CNS disorders
- Myasthenia gravis
- Peripheral neuropathy
- Renal dysfunction
- QT interval prolongation
Use of Sflox in Pregnancy and Lactation
Storage of S-FloxS-Flox tablets, injection, and other dosage forms available should be stored below 30°C in a cool & dry place. Keep all medicines out of reach of children.
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