Description and Composition of T-DoxT-Dox is a second generation semi-synthetic derivative of tetracycline antibiotic. It contains doxycycline as its active pharmaceutical ingredient plus other inactive ingredients called excipients.
Mechanism of Actions and Pharmacology T-DoxT-Dox is a bacteriostatic agent, with a wide range of anti microbial activity. It interferes with bacterial protein synthesis by reversibly binding to bacterial 30S ribosomal subunit, thus preventing the binding of aminoacyl transfer-RNA to the messenger-RNA ribosome complex. Doxycycline is readily absorbed from the gastro-intestinal tract and is excreted mainly urine.
Indications and Uses of T-Dox
- Rickettsial infections, including typhus, Rocky Mountain spotted fever and Q fever.
- Chlamydial infections, including psittacosis, lymphogranuloma venereum, trachoma
- Mycoplasmal infections, especially those caused by Mycoplasma pneumoniae, and inclusion conjunctivitis.
- Brucellosis and plague (use in association with streptomycin).
- Tularemia, chronic bronchitis, chancroid, granuloma inguinale, urinary tract infections, acne.
- Malabsorption syndromes such as tropical sprue and Whipple’s disease.
- Cholera, relapsing fever, leptospirosis and early stage of Lyme disease.
- Balantidiasis, amoebic dysentery (use in association with an amoebicide).
- Syphilis, yaws, gonorrhoea, actinomycosis, anthrax, rat bite fever and acute necrotising ulcerative gingivitis.
Contraindications of T-DoxT-Dox is not to be used in some persons and in situations if when it is indicated. Some of where it should not be used are as enlisted below.
- Avoid the use of T-Dox in patients who have shown hypersensitivity to tetracyclines.
- The use of doxycycline is not recommended during the last half of pregnancy, nursing or breastfeeding mothers and children under the age of 8 years as tetracyclines may cause permanent discolouration of the teeth, enamel hypoplasia and inhibition of linear skeletal growth.
Precautions to Observe while Using T-Dox
- Care must be taken when liver function is impaired,
- T-Dox may Interfere with some diagnostic tests including determination of urine catecholamines and glucose.
- It is unsafe in patients with porphyria
Side Effects of T-DoxSome side effects associated with the use of T-Dox including the following:
- Nausea, vomiting and diarrhoea.
- Discoloration of infant’s or children’s teeth
- Cramps or buming of the stomach.
- Sore mouth or tongue (fungal overgrowth, hypertrophy of the papilla)
- Increased sensitivity to sunlight
- Itching of the rectal or genital areas.
- Leukocytosis, neutropenia, leukopenia, atypical lymphocytes, toxic granulation of granulocytes, haemolytic anaemia, thrombocytopenia and thrombocytopenic purpura has occured.
T-Dox Drug InteractionsThis list below are drugs that interact with doxycycline and therefore should not be taken together or caution observed while using it together.
- Alkalis, aluminium hydroxide, calcium, iron and magnesium diminish the absorption of doxycycline.
- Concurrent use with penicillin, barbiturates, carbamazepine, phenytoin and sodium bicarbonate is not recommended.
- Hepatotoxic and nephrotoxic drugs should not be given with doxycycline. Examples of these drugs can be gotten from your doctor or pharmacist if needed.
Overdosage Clinical features of T-DoxIf T-Dox is overdosed, some of the symptoms and clinical features you may experience include the following:
- Perianal itching
- Skin eruption
Treatment of T-Dox OverdosageIf you overdose T-Dox, the following measures are recommended:
- Call your healthcare provider or local poison control immediately if you are an out patient.
- Emesis or gastric lavage, if appropriate; with the necessary emergency measures, if required.
Dosage and Administration of T-DoxAdults: Oral, 200 mg on the first day, then 100 mg once daily. Acne: Oral, 50 mg daily for 6 10 weeks, Note: Effect of doxycycline on teeth should be considered. Therapy should be continued for at least 10 days in group A beta-haemolytic streptococcal infections.
Storage of T-DoxHow to store T-Dox: Store below 25 C. Protect from light and moisture. Keep every medicine away from children.
Chemical Structure of T-Dox
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