Description and Composition of Unilevox
Pharmacology and Mechanism of Action of UnilevoxUnilevox is a broad-spectrum antibiotic active against both Gram positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.
Pharmacokinetics of Unilevox
Indications and Uses of UnilevoxAntibiotics usage including unilevox should be guided by Microscopy, Culture and Sensitivity test result or standard treatment guidelines of a particular country or region where MCS test is not possible. Unilevox is used in the treatment of susceptible bacterial infections including:
- Acute bacterial sinusitis
- Acute bacterial exacerbations of chronic bronchitis
- Urinary tract infections
- Bacterial Gastroenteritis
- Bone and soft tissue infections
- Gynaecological and wound infections
- Respiratory infections (nosocomial or Community acquired pneumonia)
- Acute pyelonephritis
- Chronic bacterial prostatitis
- Gram negative septicaemia
- Meningitis Prophylaxis and Conjunctivitis
- Skin and skin structure infections
Contraindications of Unilevox
Dosage of UnilevoxUnilevox should be administered as per the directions given by the physician. Unilevox tablet should be swallowed without crushing and with sufficient amount of liquid. The tablets can be taken with or without food.
Acute bacterial sinusitisAdult: 500mg daily for 10 to 14 or 750mg daily for 5 days.
Acute bacterial exacerbation of chronic bronchitisAdult: 500 mg daily for 5 days
Urinary tract infectionsComplicated or acute pyelonephritis: 750 mg daily for 5 days Uncomplicated: 250 mg daily for 10 days Uncomplicated: 250 mg daily for 3 days
Nosocomial pneumonia750 mg daily for 7 to 10 days
Community acquired pneumonia750 mg daily for 5 days 500 mg daily 7 to 10 days
Skin and skin structure infectionsComplicated: 750 mg daily for 7 to 10 days Uncomplicated: 500 mg daily for 7 to 10 days
Chronic bacterial prostatitis500 mg daily for a month (28 days)
PlagueAdult and Children weighing 50 kg and above: 500 mg daily for 10 to 14 days Children: (30 kg to 50 kg): 250 mg 12 hourly for 10 to 14 days
Post exposure therapy for inhalational anthraxAdult and Children weighing up to 50 kg: 500 mg daily for 2 months (60 days) Paediatric patients: 30 kg to 50 kg: 250 mg 12 hourly for 60 days
Acne vulgaris (Off label)100 mg PO tds for a month (28 days)
Epididymitis (off label)500 mg PO daily for 10 days
Overdosage of Unilevox
Side Effects of unilevoxSome side effects associated with the use of unilevox may include:
- Diarrhoea or constipation
- Stomach upset
Drug Interactions with unilevox
- BCG vaccine live,
- Typhoid vaccine live
- Strontium ranelate
- Aluminium hydroxide
- Cholera vaccine
- Cyclosporin A
- Multivitamins with minerals
- Phenytoin Na
- Warfarin Na.
Unilevox Disease InteractionsUnilevox interacts with the following disease conditions
- CNS disorders
- Myasthenia gravis
- Peripheral neuropathy
- Renal dysfunction
- QT interval prolongation
Use of Unilevox in Pregnancy and Lactation
Storage of UnilevoxUnilevox tablets, injection, and other dosage forms available should be stored below 30°C in a cool & dry place. Keep all medicines out of reach of children.
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