Hexatron: Uses, Dosage, Side Effects and Composition

Description and Composition of Hexatron

Hexatron is an antifibrinolytic agent. It contains Tranexamic Acid as its active pharmaceutical ingredient. It also contains inactive ingredients called excipients in sufficient quantities. Hexatron works to prevent or to control bleeding regardless of the cause. It comes in tablets and injection dosage forms. It also comes as mouth wash and as liquids for children who can’t swallow tablets. Available dosage strengths include 500 mg and 650 mg tablets, plus 100 mg/mL, and 10 mg/mL-NaCl 0.7%.

Uses of Hexatron 

  1. Hexatron is used in cyclic heavy menstrual bleeding. To be started during the menstruation.
  2. It is used in postpartum hemorrhage
  3. It is used in nose bleeding (Epistaxis).
  4. It is used in the presence of blood collection in the eyes (Hyphema).
  5. It is used to control bleeding in some surgical procedures (e.g. Cone Biopsy, during tooth extraction etc). Here, it is given intravenously for short-term use (2-8 days) especially in patients with hemophilia to prevent or reduce bleeding following tooth extraction.
  6. It is used in hereditary angioedema attack.

Dosage of Hexatron 

Tablets

2 tablets of 650mg or 500 mg to be taken two to three times a day for up to 5 days. To be taken with or without food.

Injections

500 mg in 5 ml ampoule (100 mg/ml) for slow iv injection or infusion in 0.9% sodium chloride or 5% glucose.

Not to be administered by im route

  • Adolescent under 15 years: 15 mg/kg (max. 1 g
  • Adult: 1 g (two 5 ml ampoules) in a bag of 100 ml of 0.9% sodium chloride to be administered over 15 minutes within 3 hours of delivery repeat after 30 minutes if bleeding continues or within 24 hours of the first dose if bleeding restarts (max. total dose 2 g)

Indications Based Dosage

Menorrhagia

  • 1300 mg PO TID for up to 5 days during menstruation

Hereditary Angioedema

  • Long term prophylaxis: 1000-1500 mg PO q8-12hr; reduce dose to 500 mg/dose PO qDay or q12hr when frequency of attacks reduces
  • Short term prophylaxis: 75 mg/kg/day PO divided q8-12hr for 5 days before and after the event
  • Treatment of acute HAE attack: 25 mg/kg/dose PO/IV; not to exceed 1000 mg/Y q3-4hr; not to exceed 75 mg/kg/day or 1000 mg PO q6hr for 48 hr

Epistaxis

  • 1000-1500 mg q8-12hr x10 days

Cone Biopsy

  • 1000-1500 mg q8-12hr x12 days postop

Hyphema

  • 1000-1500 mg q8-12hr x10 days

Hereditary Angioedema

1000-1500 mg PO BID/TID

Side effects of Hexatron

Some side effects you may experience while on Hexatron include:
  • Headache
  • Stomach pain
  • Muscle or joint pain
  • Muscle cramps
  • Nausea
  • Vomiting
  • Diarrhoea
You may experience other side effects other than those listed above.

How Hexatron Works

Hexatron prevents a substance called plasminogen from being activated to plasmin. This action helps the blood to clot.

Can Hexatron be Used in Pregnancy?

Hexatron seems safe but it is not indicated. In postpartum hemorrhage, it is given after delivery.

Contraindications of Hexatron

Hexatron is contraindicated:

  • In patients with acquired defective color vision, since this prohibits measuring one endpoint that should be followed as a measure of toxicity.
  • In patients  with subarachnoid hemorrhage. Anecdotal experience indicates that cerebral edema and cerebral infarction  may be caused by Tranexamic acid  in such patients.
  • Inpatients with active intravascular clotting.

Can Hexatron be Used While Breast-feeding a Baby?

It is safe

Where to Adjust Dose of Hexatron

Adjust dosage of this drug in patient with renal impairment. No dose adjustment is not necessary in hepatic impairment.

In Renal impairment

  • Serum Creatinine >1.4 mg/dL and ≤2.8 mg/dL: 1300 mg PO BID
  • Serum Creatinine >2.8 mg/dL and ≤5.7 mg/dL: 1300 mg PO qDay
  • Serum Creatinine >5.7 mg/dL: 650 mg PO qDay

Note

This write up is not a prescription. You are therefore to strictly rely and  adhere to your doctor’s prescription. Remember not to take any drug without consulting your healthcare provider.

References

  1. MSF Medical Guidelines on Tranexamic Acid
  2. MedScape Dosing of Tranexamic Acid
  3. NCBI
  4. Tranexamic Acid Drug Information