Jaflex uses, dosage, side effects and composition

Description and composition of Jaflex

Jaflex is a semisynthetic antibacterial antibiotic for oral use in the treatment of bacterial infections.

It is a first generation cephalosporin and contains cephalexin monohydrate as its active ingredient.

We have cephalexin capsules, tablets and oral suspension. Apart from these available dosage forms, we equally have different strengths of Cephalexin.

These include:

Cephalexin capsules:

  • 250 mg
  • 500 mg
  • 750 mg

Cephalexin tablets:

  • 250 mg
  • 500 mg

Cephalexin oral suspension

  • 125mg/5ml
  • 250mg/5ml

Uses of Jaflex

Jaflex antibiotic is used to treat:

  • Skin/Skin Structure Infections including burns and wound infections
  • Otitis Media
  • Bone Infections
  • Uncomplicated Cystitis
  • Genitourinary Tract Infections
  • Cellulitis and Mastitis
  • Streptococcal Pharyngitis
  • Respiratory Tract Infections
  • Gynaecological and obstetric infections
  • Septicemia

Absorption and excretion of Jaflex

Jaflex is acid stable and is rapidly absorbed after oral administration; however, food may delay its absorption.

It is widely distributed throughout the body. Maximum concentration being reached in the liver and kidneys. It does not accumulate following multiple doses; it does not enter the cerebrospinal fluid unless the meninges are inflamed but it does cross the placenta and is secreted in the breast milk 60 to 100% is excreted unchanged in the urine in 8 hours. Small elements are excreted in the bile; probenecid delays renal excretion.

Dosage and administration of Jaflex

Jaflex is better administered on an empty stomach as food affects it’s absorption. Take cephalosporin half to 1 hour before meal.

Adults:

  1. Genitourinary Tract Infections:
    • 250 mg per oral 6 hourly; dosage range, 1-4 g/day in divided doses.
  2. Bone Infections:
    • 250 mg orally 6 hourly; dosage range, 1-4 g/day in divided doses
  3. Skin/Skin Structure Infections 
    • 250 mg orally every 6 hours or 500 mg orally every 12 hours; dosage range, 1-4 g/day in divided doses
  4. Respiratory Tract Infections
    • 250 mg per oral every 6 hour; dosage range, 1-4 g/day in divided doses
  5. Streptococcal Pharyngitis
    • 250 mg orally every 6 hours or 500 mg orally every 12 hours; dosage range, 1-4 g/day in divided doses.
  6. Cellulitis and Mastitis
    • 500 mg per oral every 6 hours; dosage range, 1-4 g/day in divided doses.

Child

  1. Uncomplicated Cystitis
    • <15 years: 25-50 mg/kg/day per oral divided every 6 to 8 hours for 10 days; not to exceed 4 g/day
    • >15 years: 250 mg per oral every 6 hours; dosage range, 1-4 g/day in divided doses
  2. Genitourinary Tract Infections
    • 25-50 mg/kg/day orally divided every 6 to 8 hours for 10 days; not to exceed 4 g/day
  3. Beta-Hemolytic Streptococcal Infections 
    • 25-50 mg/kg/day orally divided every 6 to 8 hours for 10 days; not to exceed 4 g/day
  4. Bone Infections
    • 25-50 mg/kg/day per oral divided every 6 to 8 hours for 10 days; not to exceed 4 g/day
  5. Otitis Media
    • 75-100 mg/kg/day orally divided 6 hourly for 10 days; not to exceed 4 g/day
  6. Skin/Skin Structure Infections 
    • 25-50 mg/kg/day orally divided every 6 to 8 hours for 10 days; not to exceed 4 g/day
  7. Respiratory Tract Infections
      • 25-50 mg/kg/day orally divided every 6 to 8 hours for 10 days; not to exceed 4 g/day
  8. Streptococcal Pharyngitis 
    • 25-50 mg/kg per oral every 12 hours for 10 days; not to exceed 500 mg every 12 hours
  9. Cellulitis and Mastitis 
    • Adolescents: 500 mg orally every 6 hours; dosage range, 1-4 g/day in divided doses

Dosage in renal impairment

  • CrCl <10 mL/min: 250-500 mg PO q12-24hr
  • CrCl 10-50 mL/min: 500 mg PO q8-12hr
  • CrCl is creatinine clearance.

Contraindications of Jaflex

Jaflex should not be used in individuals who are allergic or hypersensitive to it.

Side effects of Jaflex

The following are the side effects of Jaflex:

  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Allergic reaction
  • Dizziness
  • Fatigue
  • Urticaria
  • Headache
  • Confusion
  • Genital pruritus
  • Angioedema
  • Possibility of pseudo-membraneous colitis exist.

Can a pregnant and breastfeeding women take Jaflex?

You should tell your doctor if you’re pregnant, planning to become pregnant or breastfeeding. Ask your doctor or pharmacist for advice before taking this medicine.

Data from a published clinical lactation study reports that cephalexin is present in human milk; relative infant dose (RID) is considered to be <1% of maternal weight adjusted dose; there are no data on effects of cephalexin on breastfed child or on milk production

Precautions

It should be used with caution in allergic patients especially when there is a history of penicillin allergy.

How to prepare oral suspension of Jaflex

  1. Shake the bottle to dispense the powder
  2. Add freshly boiled and cooled water a little above powder level; cover tightly and shake firmly.
  3. Add sufficient water up to the mark on the bottle.

How to store Jaflex

  • Capsules and tablets: store in a cool dry place, away from sunlight, not exceeding 30ºC.
  • Powder: the powder should be used stored in a cool dry place, not exceeding 30ºC and away from sunlight. The suspension should be used within 7 days of preparation and stored in a cool place preferably in a refrigerator.

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