Description and Composition of Zarlox
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Pharmacology and Mechanism of Action of Zarlox
Pharmacokinetics of Zarlox
Zarlox oral tablet is rapidly and well absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability is approximately 99% with no substantial loss by first pass metabolism. The peak serum time is between 1 to 2 hours.Indications and Uses of Zarlox
- Acute bacterial sinusitis
- Acute bacterial exacerbations of chronic bronchitis
- Urinary tract infections
- Bacterial Gastroenteritis
- Typhoid
- Bone and soft tissue infections
- Gynaecological and wound infections
- Respiratory infections (nosocomial or Community acquired pneumonia)
- Acute pyelonephritis
- Chronic bacterial prostatitis
- Gram negative septicaemia
- Meningitis Prophylaxis and Conjunctivitis
- Skin and skin structure infections
Contraindications of Zarlox
Zarlox is contraindicated in persons with a history of hypersensitivity to zarlox, any member of the quinolone class of antimicrobial agents, or any of the product components.Dosage of Zarlox
Acute bacterial sinusitis
Adult: 500mg daily for 10 to 14 or 750mg daily for 5 days.Acute bacterial exacerbation of chronic bronchitis
Adult: 500 mg daily for 5 daysUrinary tract infections
Complicated or acute pyelonephritis: 750 mg daily for 5 days Uncomplicated: 250 mg daily for 10 days Uncomplicated: 250 mg daily for 3 daysNosocomial pneumonia
750 mg daily for 7 to 10 daysCommunity acquired pneumonia
750 mg daily for 5 days 500 mg daily 7 to 10 daysSkin and skin structure infections
Complicated: 750 mg daily for 7 to 10 days Uncomplicated: 500 mg daily for 7 to 10 daysChronic bacterial prostatitis
500 mg daily for a month (28 days)Plague
Adult and Children weighing 50 kg and above: 500 mg daily for 10 to 14 days Children: (30 kg to 50 kg): 250 mg 12 hourly for 10 to 14 daysPost exposure therapy for inhalational anthrax
Adult and Children weighing up to 50 kg: 500 mg daily for 2 months (60 days) Paediatric patients: 30 kg to 50 kg: 250 mg 12 hourly for 60 daysAcne vulgaris (Off label)
100 mg PO tds for a month (28 days)Epididymitis (off label)
500 mg PO daily for 10 daysOverdosage of Zarlox
In the event of acute overdosage of zarlox, reversible renal toxicity has been reported in some cases. The stomach should be emptied by inducing vomiting or by gastric lavage. The patient should be carefully observed and given supportive treatment, including monitoring of renal function, urinary pH and acidify, if required, to prevent crystalluria and administration of magnesium, aluminum, or calcium containing antacids, which can reduce the absorption of zarlox. Adequate hydration must be maintained.Side Effects of Zarlox
- Nausea
- Vomiting
- Headache
- Diarrhoea or constipation
- Stomach upset
- Dizziness
- Insomnia
Drug Interactions with Zarlox
Zarlox is known to interact with other drugs and should not be co-administered or caution observed when doing so. Some are entirely contraindicated (C), have serious interaction, and minor. This list is not exhaustive and you’re advised to confirm with your Pharmacist or doctor for a comprehensive list.- BCG vaccine live,
- Typhoid vaccine live
- Strontium ranelate
- Aluminium hydroxide
- Cholera vaccine
- Caffeine
- Chloramphenicol
- Clozapine
- Cyclosporin A
- Multivitamins with minerals
- Pentostatin,
- Phenytoin Na
- Probenecid
- Rifampicin
- Sucralfate
- Theophylline
- Warfarin Na.
Zarlox Disease Interactions
- Diabetes
- CNS disorders
- Colitis
- Myasthenia gravis
- Peripheral neuropathy
- Renal dysfunction
- Tendonitis
- Hemodialysis
- QT interval prolongation
- Crystalluria