Description and Composition of ZillineZilline is a second generation semi-synthetic derivative of tetracycline antibiotic. It contains doxycycline as its active pharmaceutical ingredient plus other inactive ingredients called excipients.
Mechanism of Actions and Pharmacology ZillineZilline is a bacteriostatic agent, with a wide range of anti microbial activity. It interferes with bacterial protein synthesis by reversibly binding to bacterial 30S ribosomal subunit, thus preventing the binding of aminoacyl transfer-RNA to the messenger-RNA ribosome complex. Doxycycline is readily absorbed from the gastro-intestinal tract and is excreted mainly urine.
Indications and Uses of Zilline
- Rickettsial infections, including typhus, Rocky Mountain spotted fever and Q fever.
- Chlamydial infections, including psittacosis, lymphogranuloma venereum, trachoma
- Mycoplasmal infections, especially those caused by Mycoplasma pneumoniae, and inclusion conjunctivitis.
- Brucellosis and plague (use in association with streptomycin).
- Tularemia, chronic bronchitis, chancroid, granuloma inguinale, urinary tract infections, acne.
- Malabsorption syndromes such as tropical sprue and Whipple’s disease.
- Cholera, relapsing fever, leptospirosis and early stage of Lyme disease.
- Balantidiasis, amoebic dysentery (use in association with an amoebicide).
- Syphilis, yaws, gonorrhoea, actinomycosis, anthrax, rat bite fever and acute necrotising ulcerative gingivitis.
Contraindications of ZillineZilline is not to be used in some persons and in situations if when it is indicated. Some of where it should not be used are as enlisted below.
- Avoid the use of doxycycline in patients who have shown hypersensitivity to tetracyclines.
- The use of doxycycline is not recommended during the last half of pregnancy, nursing or breastfeeding mothers and children under the age of 8 years as tetracyclines may cause permanent discolouration of the teeth, enamel hypoplasia and inhibition of linear skeletal growth.
Precautions to Observe while Using Zilline
- Care must be taken when liver function is impaired,
- Zilline may Interfere with some diagnostic tests including determination of urine catecholamines and glucose.
- It is unsafe in patients with porphyria
Side Effects of ZillineSome side effects associated with the use of Zilline including the following:
- Nausea, vomiting and diarrhoea.
- Discoloration of infant’s or children’s teeth
- Cramps or buming of the stomach.
- Sore mouth or tongue (fungal overgrowth, hypertrophy of the papilla)
- Increased sensitivity to sunlight
- Itching of the rectal or genital areas.
- Leukocytosis, neutropenia, leukopenia, atypical lymphocytes, toxic granulation of granulocytes, haemolytic anaemia, thrombocytopenia and thrombocytopenic purpura has occured.
Zilline Drug InteractionsThis list below are drugs that interact with Zilline and therefore should not be taken together or caution observed while using it together.
- Alkalis, aluminium hydroxide, calcium, iron and magnesium diminish the absorption of doxycycline.
- Concurrent use with penicillin, barbiturates, carbamazepine, phenytoin and sodium bicarbonate is not recommended.
- Hepatotoxic and nephrotoxic drugs should not be given with doxycycline. Examples of these drugs can be gotten from your doctor or pharmacist if needed.
Overdosage Clinical features of ZillineIf Zilline is overdosed, some of the symptoms and clinical features you may experience include the following:
- Perianal itching
- Skin eruption
Treatment of Zilline OverdosageIf you overdose Zilline, the following measures are recommended:
- Call your healthcare provider or local poison control immediately if you are an out patient.
- Emesis or gastric lavage, if appropriate; with the necessary emergency measures, if required.
Dosage and Administration of ZillineAdults: Oral, 200 mg on the first day, then 100 mg once daily. Acne: Oral, 50 mg daily for 6 10 weeks, Note: Effect of Zilline on teeth should be considered. Therapy should be continued for at least 10 days in group A beta-haemolytic streptococcal infections.
Storage of ZillineHow to store Zilline: Store below 25 C. Protect from light and moisture. Keep every medicine away from children.
Chemical Structure of Zilline
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